Collectively we have evaluated the impact of

2018-10-20

Collectively, we have evaluated the impact of a MODY5-causing point mutation (S148L) in the HNF1B gene on human pancreas development using a unique human stem cell model. We report molecular phenotypes (up- and down-regulation of pancreatic genes) when HNF1B is increasingly expressed from days 7 to

MiR p downregulated in OM MSCs has been

2018-10-20

MiR-140-5p (downregulated in OM-MSCs) has been reported to inhibit the expression of CXCL12 (Nicolas et al., 2008), which has been shown to promote oligodendroglial cell maturation in vitro (Göttle et al., 2010; Kadi et al., 2006) and myelination in the demyelinated cuprizone model (Patel et al., 20

br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions Acknowledgments The authors thank Chyuan-Sheng Lin from the Transgenic Mouse Facility at the Herbert Irving Comprehensive Cancer Center at Columbia University for development of the Zfyve27-CreERT2 mice; Theresa Swayne from the Confocal and Speci

The CD and CD alleles

2018-10-20

The CD45.1 and CD45.2 irak pathway differ by only five amino acids within the extracellular domain (Zebedee et al., 1991), resulting in epitope changes that permit specific recognition by monoclonal antibodies (Shen, 1981). The majority of the commonly used mouse strains express the CD45.2 allele. B

br Results br Discussion Muscle recovery after

2018-10-20

Results Discussion Muscle recovery after traumatic injuries such as an occupational crush or blast suffered during military combat canonically induces a predisposition for additional injuries and chronic pain owing to incomplete regeneration of the tissue. Our understanding of how different fa

Hello world!

2018-07-29