• In this study we were able

  2018-11-12

  

  In this study, we were able to successfully delete Klf5 from the Lgr5-expressing intestinal stem gtpase inhibitor in adult mice. The short-term effect of Klf5 deletion in the intestinal and colonic stem cells was a gradual disappearance of Klf5 expression starting in the EGFP-positive stem cells and

• Since the analysis of a complete motor unit

  2018-11-12

  

  Since the analysis of a complete motor unit is essential for the understanding of pathophysiological mechanisms of motoneuron diseases (Moloney et al., 2014), or conditions involving the NMJ, we established an in vitro model of motor units. To that end, we cultivated hiPSC cell lines from healthy co

• br Immunofluorescence based detection of proteins The cells

  2018-11-12

  

  Immunofluorescence-based detection of proteins The cells were fixed with 4% paraformaldehyde for 20min at RT and washed two times with PBS. The immunofluorescence-based staining of proteins was carried out as described in Matz and Adjaye (2015). Primary dpp-4 inhibitors were used as follows: OCT4

• Acute and transient MF activation is part of the body

  2018-11-09

  

  Acute and transient MF activation is part of the body’s normal wound healing program, but persistent MFs contribute to fibrosis by excessively producing and contracting collagenous extracellular matrix (ECM) into stiff scar tissue (Hinz et al., 2012). In turn, the stiffness of mature scar promotes m

• The liver is composed of multiple cellular lineages includin

  2018-11-09

  

  The liver is composed of multiple cellular lineages, including hepatocytes, cholangiocytes (biliary epithelial cells), hepatic stellate cells, Kupffer jak inhibitors (hepatic macrophages), myofibroblasts, vascular and sinusoidal endothelial cells, and circulating hematopoietic cells. HPCs are defin

• In this article we searched for genes that are

  2018-11-09

  

  In this article, we searched for genes that are induced by KLF4 in a dose-dependent manner and identified Tcl1 as its direct target. KLF4 induces Tcl1 transcription during reprogramming via direct binding to its enhancer and promoter regions, concurrently changing repressive histone marks into activ

• heat shock protein inhibitors The most important contributio

  2018-11-09

  

  The most important contribution of our study to ZIKV research is the finding of ZIKV-mediated impairment of hNSC neuronal differentiation in a cell-strain-dependent manner. Specifically, ZIKV infection significantly reduced neuronal differentiation of K054 and K048 strains but not G010. Both RNA seq

• Due to the major differences in phenotype

  2018-11-09

  

  Due to the major differences in phenotype between human and murine GATA6 disease models, human pluripotent stem cells (PSCs) offer an alternative system for the in vitro study of GATA6. With recent developments in the genome-editing field, the use of clustered regularly interspaced short palindromic

• Our studies reveal that more than TSC patients of

  2018-11-09

  

  Our studies reveal that more than 90% TSC patients of Han Chinese develop focal sclerotic bone lesions at different locations in the skeleton. Analysis of TSC patient serum samples confirmed that bone resorption marker is reduced, whereas bone formation marker is increased. While it is assumed that

• The gene of the sigma receptor is

  2018-11-09

  

  The gene of the sigma-1 receptor is located on chromosome 9p13, known due to its being associated with psychotic disorders [6]. The sigma-1 receptor, with its small size (223 amino-acid residue), binds with medium or high affinity to a wide range of chemical compounds of very different structural cl

• where and are the radial and the axial sizes of

  2018-11-09

  

  where and are the radial and the axial sizes of the eddies, is the characteristic flow velocity. For the experiment described in this paper, the value of the axial velocity, averaged over the measurement time, for the point C on the container axis with the coordinates r = 0mm, z = 60mm (see Fig.

• We were concerned about confounding by individual

  2018-11-09

  

  We were concerned about confounding by individual SES in a zip code-matched case-control study of 13-valent pneumococcal conjugate vaccine (PCV13) effectiveness (Moore et al., 2016). PCV13 was licensed for use in children in the US in February 2010 and replaced the effective, but more limited, 7-val

• VE-822 Table presents a series of multivariate longitudinal

  2018-11-09

  

  Table 3 presents a series of multivariate longitudinal GEE logistic regression models examining the relationship between employment status and poor mental health, after accounting for the demographic, physical health, socio-economic, and psychosocial factors. Model 1 displays the increased odds of p

• Introduction The Sn and W mineral deposits in

  2018-11-09

  

  Introduction The Sn and W mineral deposits in southern China were historically suggested to have formed as part of one mineralizing event (Hsu, 1943), although the W ores are mainly distributed in the eastern part of southern China, whereas most Sn deposits are in the western part (Chen et al., 198

• Our previous study demonstrated that HDAC inhibition contrib

  2018-11-09

  

  Our previous study demonstrated that HDAC inhibition contributed to the anticancer effect of statins (Lin et al., 2008). Combining anti-cancer drugs with different mechanisms is a rational approach to improve efficacy. JMF3086, synthesized to inhibit both HDACs and HMGR, exhibits significant benefit

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