• Further insight in how exactly galanin might inhibit seizure

  2022-05-05

  

  Further insight in how exactly galanin might inhibit seizures was obtained from galanin transgenic mice. It occurred that the altered susceptibility to seizures was in direct correlation with glutamate release from hippocampal slices obtained from these animals (Fig. 2(b)). While no differences were

• The second experiment investigated the

  2022-05-05

  

  The second experiment investigated the possible neuronal mechanism underlying the effect of acupuncture. The baseline level of methamphetamine consumption in each group was similar, as in the first experiment (Fig. 2A). Acupuncture at HT7 also significantly inhibited the methamphetamine self-adminis

• In conclusion our results showed that FFAR can mediate the

  2022-05-05

  

  In conclusion, our results showed that FFAR1 can mediate the effect of PIO in attenuating β-cell lipoapoptosis through anti-oxidative stress, which may be related to the activation of the PLCγ-ERK1/2-PPARγ pathway. Our study helps not only to distinguish the role played by FFAR1 in lipotoxicity, but

• The normal function of the FBPase enzyme is to

  2022-05-05

  

  The normal function of the FBPase enzyme is to catalyze the hydrolysis of F1,6BP to F6P. This activity is induced by diabetes and starvation and is increased in diabetic rats. The level of FBPase can be normalized by insulin, however, similar information is not available from diabetic patients. FBPa

• The primary or in transit site

  2022-05-05

  

  The primary or in-transit site of metastasis for many cancers, including melanoma, are nearby sentinel lymph nodes (LNs) [6]. As such, sentinel LN biopsy is a common procedure to diagnose and stage melanoma progression [7,8]. Sentinel LNs are often the primary site of metastasis due to tumor cell-st

• According to the World Health Organization WHO classificatio

  2022-05-05

  

  According to the World Health Organization (WHO) classification, oligodendrogliomas or anaplastic oligodendrogliomas are primary neoplasms of the central nervous system, which are predominantly composed of cells morphologically resembling oligodendrocytes [23]. These tumors are often estimated to re

• We also evaluated the effect of varying ionic str http

  2022-05-05

  

  We also evaluated the effect of varying ionic strength. These experiments included previously characterized H3 (residues 1–21) and SNAIL (residues 1–9) peptides [8], [34] to allow a comparative analysis with different ligands (Fig. 1A). As shown in Fig. 2 and listed in Table 2, it is evident that a

• Interest in the non coding genome

  2022-05-05

  

  Interest in the non-coding genome has recently surfaced with accelerated emphasis in the past few years (Li et al., 2016). Transcription factors (TFs) bind to enhancers and mediate RNA initiation from distal transcriptional start sites (TSS) of genes. Epigenome sequencing of human and mouse during

• The metal nanoparticles of gold Au

  2022-05-05

  

  The metal nanoparticles of gold (Au), silver (Ag), Platinum (Pt), Palladium (Pd) and/or their composites are also being widely used to develop electrochemical sensors because of their unique advantages such as (i) ease in immobilization of receptor molecules, (ii) catalysis of electrochemical reacti

• The stud http www apexbt com media diy images wb

  2022-05-04

  

  The study was supported by Science Foundation for the Youth Scholars of Hubei Provincial Department of Education for Science and technology research program (No.: Q2017007). Introduction Chlorpyrifos is an organophosphate (OP) insecticide widely used in a variety of food crops to control a great

• br Materials and methods br Results br Discussion Although t

  2022-05-04

  

  Materials and methods Results Discussion Although there is general agreement that GPR109A has anti-lipolytic activity and that the NEFA reduction in response to nicotinic ccgs is mediated by GPR109A, whether GPR109A activation has any impact on plasma TG levels is unclear. Since the phenot

• Niacin nicotinic acid is widely used to regulate abnormaliti

  2022-05-04

  

  Niacin (nicotinic acid) is widely used to regulate abnormalities in plasma lipid and lipoprotein metabolism, as evidenced by its potential for reducing atherosclerotic cardiovascular disease risks (Guyton, 1998), due to its ability to reduce circulating triglycerides and apolipoprotein-B containing

• br Results br Discussion The twin cysteine motif is an

  2022-05-04

  

  Results Discussion The twin-cysteine motif is an evolutionary conserved motif in all primate lentiviruses except HIV-1 and some strains of SIVcpz according to sequence analysis (Bohl et al., 2013). It is assumed that only those SIVcpz which have lost the twin-cysteines successfully evolved to

• Milligan et al demonstrated the important

  2022-05-04

  

  Milligan et al. [31] demonstrated the important role of TNF-α, IL-6 and IL-1β in the development of mechanical hyperalgesia induced by intrathecal injection of gp120. Because of this work, we decide to produce and purify gp120 to develop biological systems to study pain and behavior in rodents. Intr

• br Significant efforts are currently focused

  2022-05-04

  

  Significant efforts are currently focused on non-dopaminergic strategies to address the unmet medical needs in schizophrenia, and targeting -methyl--aspartate (NMDA) hcv protease inhibitor hypofunction has garnered a great deal of attention., , Elevation of synaptic glycine levels near NMDA-contai

11289 records 139/753 page Previous Next First page 上5页 136137138139140 下5页 Last page