• The patulin in the apple

  2020-08-05

  

  The patulin in the apple juice was obtained from the rotten apple, which is contaminated by penicillium expansum. The known strategies for detoxification of patulin in apple juice include physical, biological and chemical methods. Propylthionl functionalized SBA-15 was found to reduce patulin levels

• According to previous research stress experiences have signi

  2020-08-05

  

  According to previous research, stress experiences have significant effects on the acquisition, expression, Heparin and reinstatement of CPP induced by cocaine (Logrip et al., 2011, Lu et al., 2003, Sanchez and Sorg, 2001). Previous studies in our laboratory have shown that mice exposed to social d

• Maintenance of genomic integrity is complex due to the great

  2020-08-04

  

  Maintenance of genomic integrity is complex due to the great diversity of damage that can occur in DNA. Deleterious consequences of damage accumulation may be avoided by a variety of DNA repair pathways, each recognizing and repairing specific types of DNA damage. Base excision repair (BER), nucleot

• With the narrow SAR of the tail favouring the ortho

  2020-08-04

  

  With the narrow SAR of the tail favouring the ortho sulfone group, we examined the remaining position open to substitution at the pyrazole 3-position, in an attempt to at least moderate the excessive human PPB (). Lipophilic groups in this position maintained huge shifts in potency in the absence or

• A possible explanation for these observations has been

  2020-08-04

  

  A possible explanation for these observations has been provided by a recent study showing that EWS-FLI-1 increases the Skp2-mediated 26S proteasome degradation, decreasing p27 protein stability and preventing cell senescence [42]. Mechanism of action of EWS-FLI-1 Molecular analysis has revealed

• The Eph erythropoietin producing hepatocellular family of re

  2020-08-04

  

  The Eph (erythropoietin producing hepatocellular) family of receptors make up the largest subgroup of the receptor tyrosine kinase, which could be divided into the A- or B-type based on their interactions with Ephrin ligands (20), (21). Durg et al. reported that EphA2 is an important oncogene and po

• In the context of metabolism the MMEKO mouse develops age

  2020-08-04

  

  In the context of metabolism, the MMEKO mouse develops age-related obesity. This is thought to be mediated through hyperphagia [28], although the exact mechanism is unclear. Interestingly, whole-body knockdown or overexpression of the Drosophila MME homolog NEP4 decreases larval food intake and decr

• Both the p Leu Pro

  2020-08-04

  

  Both the p.Leu610Pro and the p.Tyr740Cys substitutions are located in the kinase domain of the DDR2 receptor. To study the consequences of these substitutions, we first examined DDR2 autophosphorylation. All results were reproduced in at least two independent experiments. Control fibroblasts and fib

• The roles of ginsenoside in E and S proteasome inhibition

  2020-08-04

  

  The roles of ginsenoside in E1 and 26S proteasome inhibition are shown in Table 2. The nitro substitute on the furan ring may be important for PYR-41 inhibition of the E1 enzyme (Yang et al., 2007). The macrocycle core and aliphatic tail of Largazole are responsible for inhibiting E1 activity (Unger

• br Directions in ubiquitin probe research

  2020-08-04

  

  Directions in ubiquitin probe research Ubiquitin-based probes have proven to be valuable tools for structural studies that aim to understand substrate recognition by DUBs on a molecular level using X-ray crystallography. This was predominantly achieved using pan-DUB probes but it will now become

• A spectrum of therapies came in order to counter

  2020-08-04

  

  A spectrum of therapies came in order to counter this misfortune, some of them are discussed below. However, the common problem faced by most of these drugs is their emerging resistance after a span of time. Some of the important drugs reported so far are as: Quinine-based antimalarial drugs (Fig. 1

• br Results and discussion Our group has

  2020-08-04

  

  Results and discussion Our group has previously explored the binding cavity of Pf-DHFR against 185 diverse natural products using AutoDock (Kumar et al., 2014). Interestingly, all the xanthones displayed strong binding interactions with hydrophobic lining of binding cavity. Another very important

• In view of these facts and

  2020-08-04

  

  In view of these facts, and in continuation to our previous efforts [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], the present study reports an efficient and reproducible synthesis of a new series of 2,4-substituted-1,3-thiazoles and thiazolo[4,5-d]pyridazine bearing the 2-t

• Among prostaglandins PG PGD remained the most elusive specie

  2020-08-03

  

  Among prostaglandins (PG), PGD2 remained the most elusive species for a long time and was initially regarded as having negligible biological activity [1]. In 1974 its inhibitory effect on platelet aggregation was discovered by Smith et al. [2] and Mills & McFarlain [3], and both pressor and depresso

• br Experimental procedures This study is part of the Pharmac

  2020-08-03

  

  Experimental procedures This study is part of the Pharmacological Imaging of the Cannabinoid System (PhICS) project, the design and objectives of which are provided in a methodological paper (van Hell et al., 2011b). Results Discussion Our finding of increased perfusion after THC in bilate

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