• Nemonapride receptor Finally we investigated if calpain trun

  2021-12-20

  

  Finally, we investigated if calpain truncation affects GlyT1 turnover and trafficking. To simulate calpain cleavage at the T602/T603 and G626/S627 sites we constructed GlyT1 transporters missing the last 12 and 36 amino acids. Since the 36 amino Nemonapride receptor truncation also removes all C-te

• Elimination of the Q R bridge significantly affected the pro

  2021-12-20

  

  Elimination of the Q234–R244 bridge significantly affected the protein j 14 australia but had little effect on its activity at a permissive temperature, which may seem contrary to the known functional importance of this motif in Fpg. However, since the mutants fully or partially retained the bound z

• Several groups studied CTD mouse

  2021-12-20

  

  Several groups studied CTD mouse models, which largely mimicked the symptoms (i.e. impaired cognition and autistic-like behaviour) of the human disease (Kurosawa et al., 2012; Baroncelli et al., 2016; Stockebrand, 2018). The CRT-1 knockout mice showed a drastic deterioration in the GABAergic system,

• The rapid actions of glucocorticoids range from the

  2021-12-20

  

  The rapid actions of glucocorticoids range from the production of endocannabinoid as a retrograde messenger [9], to regulation of ion channels [10], [11], to inhibitory effects on immune Insulin (human) recombinant expressed in yeast [12], [13], [14]. Many different kinase signaling pathways have b

• 94 8 mg br Discussion According to the

  2021-12-20

  

  Discussion According to the generally accepted notion which originated from the study of ATP-depleted 94 8 mg the changes in Ca2+ homeostasis induced by ATP depletion and leading to the activation of the Gárdos effect are due to the inhibition of Ca2+ pumping, and the subsequent entry of Ca2+ thr

• br Materials and methods br Results br Discussion br

  2021-12-20

  

  Materials and methods Results Discussion Acknowledgments This work was financially supported by the University of Tehran, Iran. The authors thank all the teams who worked on the experiments and who provided technical assistance in the laboratory during this study. We also thank the anony

• br Discussion According to the

  2021-12-20

  

  Discussion According to the generally accepted notion which originated from the study of ATP-depleted smo inhibitor the changes in Ca2+ homeostasis induced by ATP depletion and leading to the activation of the Gárdos effect are due to the inhibition of Ca2+ pumping, and the subsequent entry of Ca

• br Presenilins and Wnt catenin signalling

  2021-12-20

  

  Presenilins and Wnt/β-catenin signalling Several groups have provided substantial data indicating that PS1 acts as a negative modulator of the transcriptional activity of the β-catenin/Tcf-4 complex (Fig. 4) [120], [121], [122]. β-Catenin is a multifunctional protein that was first described as a

• br Hydroxyfarnesyl diphosphate was synthesised

  2021-12-20

  

  12-Hydroxyfarnesyl diphosphate (6) was synthesised in three steps starting from commercially available (E,E)-farnesol (10) (Scheme 5). Chlorination of 10 gave farnesyl chloride (11) in a quantitative yield, which was carried forward without purification. The following step was a selenium dioxide-c

• H O induced astrocyte ATP

  2021-12-20

  

  H2O2 induced astrocyte ATP release through lysosome exocytosis. The LDH assay and electric microscope results indicated that the increase of extracellular ATP concentration was not due to the cell rupture, but the alternations in cell activities. In addition, when lysosome exocytosis was blocked by

• A number of in vivo studies have investigated the

  2021-12-18

  

  A number of in vivo studies have investigated the antitumor activity of distinct GSK-3 inhibitors in a variety of cancer cell line-derived tumor xenograft models [14], [21], [22], [24], [33], [39], [40]. These studies utilized toolkit GSK-3 inhibitors as monotherapies. Although inhibition of tumor g

• Introduction The onset of uterine labor

  2021-12-18

  

  Introduction The onset of uterine labor is the culmination of a gradual uterine activation wherein physiological inflammation induces a common prolabor pathway characterized by increased myometrial contractility, weakening of fetal membrane integrity, and cervical ripening. Pathological proinflamma

• C steroids and their glycosylation products

  2021-12-18

  

  C21 steroids and their glycosylation products distribute widely in Asclepiadaceae plants. Their anticancer activities have been shown in different human cell lines and in vivo animal experiments [[27], [28], [29], [30], [31], [32]]. However, the mechanisms of their anticancer activities are still un

• Deferiprone br Materials and methods br Results br Discussio

  2021-12-18

  

  Materials and methods Results Discussion Our data show that the ghrelin receptor, Ghsr, links energy homeostasis with a form of adult hippocampal plasticity. The presence of Ghsr on mature DG neurons suggest that acyl-ghrelin may modulate NSPCs indirectly, possibly via soluble factors such

• The significance of A and

  2021-12-17

  

  The significance of Aβ and tau as therapeutic targets is not only derived from pathological evidence of postmortem brain but also from biochemical analysis of cultured human neurons. This is largely based on the induced pluripotent stem cell (iPSC) technology that has been established to study Aβ, t

15650 records 505/1044 page Previous Next First page 上5页 501502503504505 下5页 Last page