• A new study by Zimerman and colleagues in

  2018-10-23

  

  A new study by Zimerman and colleagues in this issue of is one of the first to attempt to confirm animal-generated hypotheses in human patients and is of significant interest to NF1 cognitive research (). The authors examined the relationship between inhibitory GABAergic neurotransmission and motor

• Utilizing a recently developed ultrasensitive

  2018-10-23

  

  Utilizing a recently developed ultrasensitive assay for vitamin C in RBCs and physiologic transport conditions (Li et al., 2012), we propose an original multicomponent hypothesis linking vitamin C to diabetes. The parts of the hypothesis investigated here are whether low ascorbate concentrations occ

• INNO-406 We previously identified JACIE accreditation as a c

  2018-10-23

  

  We previously identified JACIE accreditation as a center-specific factor after allogeneic HSCT and found indications for an effect of patient volume (Gratwohl et al. 2014). We used this INNO-406 well-defined large cohort of patients to investigate the multifaceted relationship between potential cen

• The ethambutol concentrations achieved in pericardial fluid

  2018-10-23

  

  The ethambutol concentrations achieved in pericardial fluid are shown in Fig. 3A. The figure shows that significantly lower ethambutol concentrations were achieved in pericardium compared to plasma (pretinoic acid falls based on the Henderson–Hasselbach relationship (Zhang et al., 2002). We measure

• br Hedgehog Pathway Inhibition Hedgehog Hh is a highly conse

  2018-10-23

  

  Hedgehog Pathway Inhibition Hedgehog (Hh) is a highly conserved signaling pathway, components of which include cell surface receptor Patched-1 (PTCH1), transmembrane receptor Smoothened (SMO), and three glioma associated family transcription factors (GLI) (Khan et al., 2015). It is involved with

• In human cancer ABCB P gp ABCC multidrug resistance associat

  2018-10-23

  

  In human cancer, ABCB1/P-gp, ABCC1/multidrug resistance-associated protein 1 (MRP1), and ABCG2/breast cancer resistance protein (BCRP) are well-known causes of multidrug resistance to multiple chemotherapeutic agents, such as taxane and vinca alkaloids (Gottesman et al., 2002). Therefore, much effor

• br The Role of Glucose Metabolism in HIV Pathogenesis br

  2018-10-23

  

  The Role of Glucose Metabolism in HIV Pathogenesis Metabolic Regulation of Monocytes Monocytes dramatically change their metabolic phenotype from oxidative to glycolytic metabolism when activated in humans (Dietl et al., 2010; Cramer et al., 2003), similar to what is observed in T cells. In a

• We also found that q does not

  2018-10-23

  

  We also found that 1q+ does not show preference in evolutionary timing—it may occur as an early or late event—which suggests that its oncogenic effect is independent of other genetic changes. Therefore, we suspect that 1q+ may have a similar effect on WT outcome regardless of whether it is homogeneo

• Most studies have been focused on investigating

  2018-10-23

  

  Most studies have been focused on investigating the molecular control of GPCR ubiquitination by identifying the E3 ubiquitin ligase, while the little information is available for deubiquitination of GPCR by deubiqutinating enzymes. Here we report that a deubiquitinating enzyme, USP11, promotes LPA1

• br Grant Support This work was

  2018-10-23

  

  Grant Support This work was supported by a research grant from the National Science Council, Taiwan and the Institute of Biomedical Sciences, Academia Sinica (IBMS-CRC103-P02). Conflicts of Interest Author Contributions Introduction Because of late presentation and chemotherapy resistan

• Our previous study demonstrated that

  2018-10-23

  

  Our previous study demonstrated that HDAC inhibition contributed to the anticancer effect of statins (Lin et al., 2008). Combining anti-cancer drugs with different mechanisms is a rational approach to improve efficacy. JMF3086, synthesized to inhibit both HDACs and HMGR, exhibits significant benefit

• Duchenne Muscular Dystrophy DMD is

  2018-10-23

  

  Duchenne Muscular Dystrophy (DMD) is a severe muscle disease affecting 1:3500 male births. DMD is caused by a mutation in dystrophin gene, coding for a protein required for skeletal and cardiac muscle integrity (Mercuri and Muntoni, 2013; Muntoni, 2003; Muntoni et al., 2003). Indeed, dystrophin is a

• br Results The study flow

  2018-10-23

  

  Results The study flow diagram is shown in Fig. 1. Baseline characteristics of patients included in the final analysis are shown in Table 1. There were 197 patients treated with IPI and 65 treated with a BRAFi who had pretreatment CBC available. Median time from baseline CBC to first dose of trea

• Here we show that the genetic disruption of

  2018-10-23

  

  Here, we show that the genetic disruption of the regulatory system maintaining systemic iron homeostasis causes age-dependent and genotype-specific pulmonary iron accumulation, increased lipid peroxidation, and gene responses consistent with pulmonary iron overload and oxidative stress; TfR1 and DMT

• br Search Strategy and Selection Criteria br

  2018-10-23

  

  Search Strategy and Selection Criteria Conflicts of Interest Acknowledgments Introduction Chronological age is a major risk factor for functional impairments, chronic diseases and mortality. However, there is still great heterogeneity in the health outcomes of older individuals (Lowsky e

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