• Our results are the first to demonstrate that ERR acts

  2019-09-06

  

  Our results are the first to demonstrate that ERRγ acts as a catabolic regulator of cartilage degeneration and OA pathogenesis, and collectively support the idea that ERRγ could be a therapeutic target for OA Introduction DNA cytosine-5-methyltransferases (Dnmts) catalyze the methyl transfer fr

• The H E staining and

  2019-09-06

  

  The H&E staining and Nissl staining results showed that damage to the pyramidal neurons in the CA1 and CA3 regions of the hippocampus were observed in the 50 mg/kg/day DBP group, accompanied by an absence of Nissl bodies, suggesting that DBP exposure can lead to pathological changes in the neurons o

• These data from developing brain are in contrast to noradren

  2019-09-06

  

  These data from developing ache inhibitors are in contrast to noradrenergic receptor regulation in the adult brain. In adult animals, a persistent increase in the α2-AR high affinity state is elicited as a result of DSP-4 lesion or reserpinization, as measured by [3H]clonidine binding to membrane p

• br Methods To study electrostatic substrate channeling we em

  2019-09-06

  

  Methods To study electrostatic substrate channeling, we employed two methodologies, Brownian dynamics and a continuum model based on the Smoluchowski theory. Whereas Brownian dynamics simulations are useful for tracking the motion of individual particles, the continuum model is convenient for cal

• To better understand Wolbachia s

  2019-09-06

  

  To better understand Wolbachia’s dependence on these enzymes, RNAi experiments targeting these transcripts will be required to examine the consequences of their down-regulation on Wolbachia in the different tissues of the parasite. Initial studies have shown that decreases in Bm-cpl-3 and Bm-cpl-6 t

• FPH2 mass The role of ARA cyp metabolites

  2019-09-06

  

  The role of ARA-cyp450 metabolites in the liver is still unclear [44]. However, ARA-cyp450 genes metabolize other fatty acids such lauric and palmitic FPH2 mass [45]. It was found that decreased cyp4a expression caused fatty livers through reduction of fatty acid metabolism [46]. In this study, we f

• Ro 48-8071 br Introduction Analyses of genomic alterations i

  2019-09-06

  

  Introduction Analyses of genomic alterations in cancer have identified epidermal growth factor receptor (EGFR) as one of the most potent “oncogenic driver” kinases that is present in many epithelial tumors including endometrial, breast, prostate, skin, esophagus, lung, stomach, colorectal, and re

• Calcein AM br Methods br Results br Discussion The lowest

  2019-09-06

  

  Methods Results Discussion The lowest intra-CeA dose of R278995/CRA0450 that prevented the elevations in Calcein AM reward thresholds associated with nicotine withdrawal was 0.05μg/side (0.1μg total bilateral dose). The total bilateral dose in the present study is 100 times lower than the

• Cryoprotectant equilibration and the response to ice concent

  2019-09-06

  

  Cryoprotectant equilibration and the response to ice concentrated media are the two facets of cellular cryobiological protocols most commonly covered by mathematical modeling. In these models, Liproxstatin-1 are typically assumed to have uniform, spatially independent extracellular concentrations a

• The current study showed that the tested nonselective COX

  2019-09-06

  

  The current study showed that the tested nonselective COX inhibitors potentiated the neuronal (EFS) and endothelial (ACh)-dependent relaxation of rat corpus cavernosum. Indomethacin was the most effective among them in potentiating EFS-induced relaxation. Diclofenac was the most effective in potenti

• Simulation methods In our study the TIP P model is

  2019-09-05

  

  Simulation methods In our study, the TIP3P model is applied for water, AMBER99sb force field [24] is used to describe three types of EGFR, including the wild type (PDB: 2ITY) [25], its mutant G719S (PDB: 2ITO) [25] and mutant T790M (PDB: 3IKA) [26]. The force field of Tubemoside molecule is paramet

• br E mediated E discharge E

  2019-09-05

  

  E3-mediated E2 discharge E3 ligases simultaneously interact with the substrate and the SUMOD charged E2 enzyme to catalyze the discharge of the thioester-bound SUMOD from the E2 to the substrate. E3 interaction with SUMOD via a SIM results in a closed conformation which is highly reactive and lea

• br Results and discussion br

  2019-09-05

  

  Results and discussion Conclusion Experimental section Pharmacological studies Introduction Survival analysis is a set of statistical methods that aim at modeling the relationship between a set of predictor variables and an outcome variable and, in particular, prediction of the time w

• Based on the SUMO SIM interaction involved in SUMOD position

  2019-09-05

  

  Based on the SUMO–SIM interaction involved in SUMOD positioning, a SUMO2ΔSBD (SIM-binding domain; Q30A, F31A, I33A) mutant can be investigated that disrupts this important binding interface (Eisenhardt et al., 2015; Meulmeester, Kunze, Hsiao, Urlaub, & Melchior, 2008). In Fig. 4A, multiturnover assa

• The previously described endogenous patterns of IGF induced

  2019-09-05

  

  The previously described endogenous patterns of IGF-1-induced kinase signaling, and resulting interaction between MAPK and PI3K, differ across neuronal sub-types. In R28 retinal neuron-like cells, IGF-1 treatment elicits prolonged activation (at least 80 min) of both PI3K and MAPK (Kong et al., 2016

15650 records 944/1044 page Previous Next First page 上5页 941942943944945 下5页 Last page