The aim of this study was to

2018-10-20

The aim of this study was to determine the growth rate of human dental pulp stem hesperetin (hDPSCs) under physiological oxygen tension (3%), and to investigate the cell signaling pathways underlying decreased stem cell proliferation during routine culture under ambient oxygen tension (21%). We sho

br Acknowledgments br Introduction The intestinal epithelium

2018-10-20

Acknowledgments Introduction The intestinal epithelium provides a paradigmatic model for understanding stem cell organization and dynamics in highly proliferative tissues. The past decade has seen numerous breakthroughs in our understanding of intestinal stem cells (ISCs). Prior to 2007, the e

The expression profiles of the three distinct cell populatio

2018-10-20

The expression profiles of the three distinct cell populations show a high correlation in 3-week-old virgin mice, which represents the prepubertal immature mammary gland, but become very distinct with puberty and even more so during pregnancy, whereas bcl-xl inhibitor from retired breeders resemble

The pluripotency of the RbiPSC line was

2018-10-20

The pluripotency of the RbiPSC line was examined by immunocytochemistry staining, using THZ1 Hydrochloride against human OCT4, SOX2, and SSEA4 (Fig. 1A). The in vitro spontaneous differentiation potential towards the three germ layer of RbiPSC line was demonstrated by the expression of ectodermal (

Compared to treatments with other FGF isoforms

2018-10-20

Compared to treatments with other FGF2 isoforms, stimulation with 22.5kDa FGF2 results in lower stem cell gene expression in hESCs (Fig. 4d), weaker proliferative activity in human dermal fibroblasts (Fig. 5), and lower relative mitogenic activity in BaF3 ppar antagonist ectopically expressing FGFR

Induced pluripotent stem cell iPSC technology

2018-10-20

Induced pluripotent stem cell (iPSC) technology (Jin et al., 2012; Singh et al., 2013; Takahashi and Yamanaka, 2006; Tucker et al., 2013a,b, 2014a, 2015) makes it possible to derive cell types in vitro that would otherwise be inaccessible in living patients. This in turn allows one to evaluate the p

br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction The mammalian adult cerebral cortex has a limited capacity to regenerate lost neural tissue after ldv damage, due to the limited ability of the neural precursor cell (NPC) population residing in the two neurogenic

Recent advances in stem cell biology have greatly

2018-10-20

Recent advances in stem cell biology have greatly increased the efficiency of cardiac differentiation of human pluripotent stem buy TL32711 (Lian et al., 2012). Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are now used widely for in vitro studies (Sun et al., 2012) and as cell sour

An increase in the PGC number

2018-10-20

An increase in the PGC number caused by dnd RNA injection does not exceed 3-fold, even if a high level of Dnd expression occurs in many cells. It is likely that an additional factor essential for PGC specification exists in medaka, which shows expression and PGC-specifying activity similar to dnd bu

Collectively we have evaluated the impact of

2018-10-20

Collectively, we have evaluated the impact of a MODY5-causing point mutation (S148L) in the HNF1B gene on human pancreas development using a unique human stem cell model. We report molecular phenotypes (up- and down-regulation of pancreatic genes) when HNF1B is increasingly expressed from days 7 to

MiR p downregulated in OM MSCs has been

2018-10-20

MiR-140-5p (downregulated in OM-MSCs) has been reported to inhibit the expression of CXCL12 (Nicolas et al., 2008), which has been shown to promote oligodendroglial cell maturation in vitro (Göttle et al., 2010; Kadi et al., 2006) and myelination in the demyelinated cuprizone model (Patel et al., 20

br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions Acknowledgments The authors thank Chyuan-Sheng Lin from the Transgenic Mouse Facility at the Herbert Irving Comprehensive Cancer Center at Columbia University for development of the Zfyve27-CreERT2 mice; Theresa Swayne from the Confocal and Speci

The CD and CD alleles

2018-10-20

The CD45.1 and CD45.2 irak pathway differ by only five amino acids within the extracellular domain (Zebedee et al., 1991), resulting in epitope changes that permit specific recognition by monoclonal antibodies (Shen, 1981). The majority of the commonly used mouse strains express the CD45.2 allele. B

br Results br Discussion Muscle recovery after

2018-10-20

Results Discussion Muscle recovery after traumatic injuries such as an occupational crush or blast suffered during military combat canonically induces a predisposition for additional injuries and chronic pain owing to incomplete regeneration of the tissue. Our understanding of how different fa

Hello world!

2018-07-29